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DNA RELAXING ENZYME
Descriptors Found:
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DeCS
Descriptor
English
:
DNA Topoisomerases, Type I
Descriptor
Spanish
:
Topoisomerasas de ADN Tipo I
Descriptor
Portuguese
:
DNA Topoisomerases Tipo I
Synonyms
English
:
DNA Nicking-Closing Protein
DNA Relaxing Enzyme
DNA Relaxing Protein
DNA Topoisomerase
DNA Topoisomerase I
DNA Untwisting Enzyme
DNA Untwisting Protein
Tree Number:
D08.811.399.403.483
Definition
English
:
DNA TOPOISOMERASES
that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand.
DNA Topoisomerases
, Type I
enzymes
reduce the topological stress in the DNA structure by relaxing the superhelical turns and knotted rings in the DNA helix.
Indexing Annotation
English
:
do not confuse entry term DNA UNTWISTING PROTEIN with
DNA UNWINDING PROTEINS
see
DNA HELICASES
; coordinate with
BACTERIAL PROTEINS
or
ARCHAEAL PROTEINS
if pertinent
Entry Combination - descr/qualif
English
:
DNA Topoisomerases, Type I
/
antagonists & inhibitors
use
Topoisomerase I Inhibitors
History Note
English
:
2002
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
31732
Unique Identifier:
D004264
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS