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EPIDERMAL GROWTH FACTOR-UROGASTRONE
Descriptors Found:
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DeCS
Descriptor
English
:
Epidermal Growth Factor
Descriptor
Spanish
:
Factor de Crecimiento Epidérmico
Descriptor
Portuguese
:
Fator de Crescimento Epidérmico
Synonyms
English
:
Epidermal Growth Factor-Urogastrone
Urogastrone
EGF
Tree Number:
D06.472.317.350
D12.644.276.382.500
D12.776.467.382.500
D23.529.382.500
Definition
English
:
A 6-kDa polypeptide
growth
factor initially discovered in mouse submaxillary glands. Human
epidermal growth factor
was originally isolated from urine based on its ability to inhibit gastric secretion and called urogastrone.
Epidermal growth factor
exerts a wide variety of biological effects including the promotion of proliferation and differentiation of mesenchymal and
EPITHELIAL CELLS
. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form.
See Related
English
:
Anti-Ulcer Agents
Gastrointestinal Agents
Receptor, Epidermal Growth Factor
History Note
English
:
2000(1982); use PEPTIDES 1977-1981; for UROGASTRONE use GASTROINTESTINAL HORMONES 1963-1981
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
4896
Unique Identifier:
D004815
Occurrence in VHL
:
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