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HIRUDINS
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DeCS
Descriptor
English
:
Hirudins
Descriptor
Spanish
:
Hirudinas
Descriptor
Portuguese
:
Hirudinas
Synonyms
English
:
Hirudin
Tree Number:
D12.644.861.060.875
D12.776.872.060.875
Definition
English
:
Single-chain
polypeptides
of about 65
amino acids
(7 kDa) from
LEECHES
that have a neutral hydrophobic N terminus, an acidic hydrophilic C terminus, and a compact, hydrophobic core region. Recombinant
hirudins
lack tyr-63 sulfation and are referred to as 'desulfato-hirudins'. They form a stable non-covalent complex with ALPHA-THROMBIN, thereby abolishing its ability to cleave
FIBRINOGEN.
Pharmacological Action:
Antithrombins
Fibrinolytic Agents
Entry Combination - descr/qualif
English
:
Hirudins
/
therapeutic use
use
Hirudin Therapy
History Note
English
:
2005(1963)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
29410
Unique Identifier:
D006629
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS