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PROTOPORPHYRINOGEN OXIDASE
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DeCS
Descriptor
English
:
Protoporphyrinogen Oxidase
Descriptor
Spanish
:
Protoporfirinógeno-Oxidasa
Descriptor
Portuguese
:
Protoporfirinogênio Oxidase
Tree Number:
D08.811.682.660.600
D12.776.543.697
Definition
English
:
A membrane-bound flavoenzyme that catalyzes the oxygen-dependent aromatization of protoporphyrinogen IX (Protogen) to protoporphyrin IX (Proto IX). It is the last enzyme of the common branch of the HEME and
CHLOROPHYLL
pathways in
plants
, and is the molecular target of diphenyl ether-type
herbicides
. VARIEGATE PORPHYRIA is an autosomal dominant disorder associated with deficiency of
protoporphyrinogen oxidase.
Entry Combination - descr/qualif
English
:
Protoporphyrinogen Oxidase
/
deficiency
use
Porphyria, Variegate
History Note
English
:
2006(1975)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
50629
Unique Identifier:
D050768
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
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