Expresión de búsqueda:
SIRTUINS
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DeCS
Descriptor
Inglés
:
Sirtuins
Descriptor
Español
:
Sirtuinas
Descriptor
Portugués
:
Sirtuínas
Sinónimos
Inglés
:
Sir2-like Proteins
Categoría:
D08.811.277.087.520.200.650
D08.811.913.400.725.115.961
D12.776.476.900
Definición
Inglés
:
A homologous
family
of regulatory
enzymes
that are structurally related to the protein silent mating type
information
regulator 2 (Sir2) found in
Saccharomyces cerevisiae
.
Sirtuins
contain a central catalytic core region which binds NAD. Several of the
sirtuins
utilize NAD to deacetylate
proteins
such as
HISTONES
and are categorized as
GROUP III HISTONE DEACETYLASES
. Several other sirtuin members utilize NAD to transfer ADP-RIBOSE to
proteins
and are categorized as MONO ADP-RIBOSE
TRANSFERASES
, while a third group of
sirtuins
appears to have both deacetylase and ADP
ribose
transferase activities.
Relacionados
Inglés
:
Silent Information Regulator Proteins, Saccharomyces cerevisiae
Nota Histórica
Inglés
:
2003
Calificadores Permitidos
Inglés
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Número del Registro:
37322
Identificador Único:
D037761
Ocurrencia en la BVS
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS