Search on:
(3-IODO-(131I)BENZYL)GUANIDINE
Descriptors Found:
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DeCS
Descriptor
English
:
3-Iodobenzylguanidine
Descriptor
Spanish
:
3-Yodobencilguanidina
Descriptor
Portuguese
:
3-Iodobenzilguanidina
Synonyms
English
:
(3-Iodo-(131I)benzyl)guanidine
Iobenguane
MIBG
Tree Number:
D02.078.370.510
D02.455.426.559.389.454.300
D02.455.526.581.496.300
Definition
English
:
A
guanidine
analog with specific affinity for
tissues
of the
sympathetic nervous system
and related tumors. The radiolabeled forms are used as
antineoplastic agents
and radioactive imaging agents. (Merck Index, 12th ed) MIBG serves as a neuron-blocking agent which has a strong affinity for, and retention in, the
adrenal medulla
and also inhibits ADP-ribosyltransferase.
Pharmacological Action:
Antineoplastic Agents
Enzyme Inhibitors
Radiopharmaceuticals
History Note
English
:
98; use 3-IODOBENZYLGUANIDINE (NM) 1980-97
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
EC
economics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
33386
Unique Identifier:
D019797
Occurrence in VHL
:
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