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DeCS
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Descriptor English:
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Zalcitabine
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Descriptor Spanish:
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Zalcitabina
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Descriptor Portuguese:
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Zalcitabina
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Synonyms English:
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ddC (Antiviral)
2',3'-Dideoxycytidine
Dideoxycytidine
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Tree Number:
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D03.383.742.680.245.500.950
D13.570.230.329.950
D13.570.230.500.925
D13.570.685.245.500.950
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Definition English:
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A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal toxic side effect is axonal degeneration resulting in peripheral neuropathy. |
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Pharmacological Action:
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Anti-HIV Agents
Antimetabolites
Reverse Transcriptase Inhibitors
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History Note English:
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94; was DIDEOXYCYTIDINE 1990-93
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Allowable Qualifiers English:
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Record Number:
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31821
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Unique Identifier:
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D016047
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Occurrence in VHL:
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Similar:
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DeCS CID-10 SciELO LILACS LIS
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