Search on: 3,4-DIHYDROXYPHENYLSERINE 
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Descriptor English:   Droxidopa 
Descriptor Spanish:   Droxidopa 
Descriptor Portuguese:   Droxidopa 
Synonyms English:   3,4-Dihydroxyphenylserine  
Tree Number:   D02.092.211.215.311.560.220
D02.092.311.461.484.220
D12.125.154.800.875
Definition English:   A precursor of noradrenaline that is used in the treatment of parkinsonism. The racemic form (DL-threo-3,4-dihydroxyphenylserine) has also been used, and has been investigated in the treatment of orthostatic hypotension. There is a deficit of noradrenaline as well as of dopamine in Parkinson's disease and it has been proposed that this underlies the sudden transient freezing seen usually in advanced disease. Administration of DL-threo-3,4-dihydroxyphenylserine has been claimed to result in an improvement in this phenomenon but controlled studies have failed to demonstrate improvement. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995) 
Pharmacological Action:   Antiparkinson Agents
 
History Note English:   97; was 3,4-DIHYDROXYPHENYLSERINE 1975-96 (see under SERINE 1975-90); DOPS was see DIHYDROXYPHENYLSERINE 1975-96 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AA analogs & derivatives
AN analysis AI antagonists & inhibitors
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
EC economics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UR urine
Record Number:   4140 
Unique Identifier:   D015103 

Occurrence in VHL:
 

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