Search on:
4-NITROPHENOL-2-HYDROXYLASE
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DeCS
Descriptor
English
:
Cytochrome P-450 CYP2E1
Descriptor
Spanish
:
Citocromo P-450 CYP2E1
Descriptor
Portuguese
:
Citocromo P-450 CYP2E1
Synonyms
English
:
CYP2E1
Dimethylnitrosamine N-Demethylase
4-Nitrophenol-2-Hydroxylase
Tree Number:
D08.244.453.300
D08.811.682.662.582.338
D08.811.682.690.708.170.200
D12.776.422.220.453.300
Definition
English
:
An ethanol-inducible cytochrome P450 enzyme that metabolizes several precarcinogens, drugs, and
solvents
to reactive metabolites.
Substrates
include
ETHANOL
;
INHALATION ANESTHETICS
;
BENZENE
;
ACETAMINOPHEN
and other low
molecular weight
compounds. CYP2E1 has been used as an enzyme marker in the study of alcohol abuse.
Indexing Annotation
English
:
do not confuse with other cytochrome P-450 CYP's
Entry Combination - descr/qualif
English
:
Cytochrome P-450 CYP2E1
/
antagonists & inhibitors
use
Cytochrome P-450 CYP2E1 Inhibitors
History Note
English
:
97; was DIMETHYLNITROSAMIME N-DEMETHYLASE (NM) 1972-96 & was 4-NITROPHENOL-2-HYDROXYLASE (NM) 1984-96
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
33012
Unique Identifier:
D019392
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS