Search on: 6-PHOSPHOFRUCTO-2-KINASE-FRUCTOSE-2,6-BISPHOSPHATASE 
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Descriptor English:   Phosphofructokinase-2 
Descriptor Spanish:   Fosfofructoquinasa-2 
Descriptor Portuguese:   Fosfofrutoquinase-2 
Synonyms English:   6-Phosphofructo-2-kinase
6-Phosphofructo-2-kinase-fructose-2,6-bisphosphatase
Fructose-2,6-bisphosphatase  
Tree Number:   D08.811.277.352.650.622
D08.811.641.843
D08.811.913.696.620.225.850.750
Definition English:   An allosteric enzyme that regulates glycolysis and gluconeogenesis by catalyzing the transfer of a phosphate group from ATP to fructose-6-phosphate to yield fructose-2,6-bisphosphate, an allosteric effector for the other 6-phosphofructokinase, PHOSPHOFRUCTOKINASE-1. Phosphofructokinase-2 is bifunctional: the dephosphorylated form is a kinase and the phosphorylated form is a phosphatase that breaks down fructose-2,6-bisphosphate to yield fructose-6-phosphate. 
See Related English:   Phosphofructokinase-1
 
History Note English:   2002; for 6-PHOSPHOFRUCTO-2-KINASE use PHOSPHOTRANSFERASES (NM) 1993-2001, use PHOSPHOTRANSFERASES, ATP (NM) 1981-1993; for FRUCTOSE-2,6-BISPHOSPATASE use PHOSPHORIC MONOESTER HYDROLASES (NM) 1983-2001; for 6-PHOSPHOFRUCTO-2-KINASE-FRUCTOSE-2,6-BISPHOSPHATASE use FRUCTOSE-BISPHOSPHATASE (NM) 1990-2001, use MULTIENZYME COMPLEXES (NM) 1990-2001, use PHOSPHOFRUCTOKINASE-1 (NM) 1990-2001 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   36081 
Unique Identifier:   D025481 

Occurrence in VHL:
 

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