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ABATACEPT
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DeCS
Descriptor
English
:
Abatacept
Descriptor
Spanish
:
Abatacept
Descriptor
Portuguese
:
Abatacepte
Tree Number:
D12.776.124.486.485.114.580.225
D12.776.124.790.651.114.580.225
D12.776.377.715.548.114.580.225
Definition
English
:
A fusion protein immunoconjugate of the extracellular domain of CTLA4 and the Fc domain of human IgG1. It functions as a T-cell co-stimulation blocker that inhibits TNF-ALPHA and prevents the activation of
T-LYMPHOCYTES
. It is used in the treatment of
RHEUMATOID ARTHRITIS.
History Note
English
:
2016 (2002)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CH
chemistry
CL
classification
CT
contraindications
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
55984
Unique Identifier:
D000069594
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS