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AMIODARONE
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DeCS
Descriptor
English
:
Amiodarone
Descriptor
Spanish
:
Amiodarona
Descriptor
Portuguese
:
Amiodarona
Tree Number:
D03.438.127.075
Definition
English
:
An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting
POTASSIUM CHANNELS
and
VOLTAGE-GATED SODIUM CHANNELS
. There is a resulting decrease in
heart rate
and in
vascular resistance.
Pharmacological Action:
Anti-Arrhythmia Agents
Cytochrome P-450 CYP1A2 Inhibitors
Cytochrome P-450 CYP2C9 Inhibitors
Cytochrome P-450 CYP2D6 Inhibitors
Cytochrome P-450 CYP3A Inhibitors
Potassium Channel Blockers
Sodium Channel Blockers
Vasodilator Agents
History Note
English
:
87(75); was see under BENZOFURANS 1975-86
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
EC
economics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
651
Unique Identifier:
D000638
Occurrence in VHL
:
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DeCS
CID-10
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