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CLOTRIMAZOLE
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DeCS
Descriptor
English
:
Clotrimazole
Descriptor
Spanish
:
Clotrimazol
Descriptor
Portuguese
:
Clotrimazol
Tree Number:
D03.383.129.308.175
Definition
English
:
An imidazole derivative with a broad spectrum of antimycotic activity. It inhibits biosynthesis of the sterol ergostol, an important component of fungal CELL
MEMBRANES
. Its action leads to increased membrane
permeability
and apparent disruption of enzyme systems bound to the membrane.
Pharmacological Action:
14-alpha Demethylase Inhibitors
Anti-Infective Agents, Local
Antifungal Agents
History Note
English
:
91(75); was see under IMIDAZOLES 1975-90
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
EC
economics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
3049
Unique Identifier:
D003022
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
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