Search on: DISINTEGRINS 
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Descriptor English:   Disintegrins 
Descriptor Spanish:   Desintegrinas 
Descriptor Portuguese:   Desintegrinas 
Tree Number:   D12.644.138
Definition English:   A family of polypeptides purified from snake venoms, which contain the arginine-glycine-aspartic acid (RGD) sequence. The RGD tripeptide binds to integrin receptors and thus competitively inhibits normal integrin-ligand interactions. Disintegrins thus block adhesive functions and act as platelet aggregation inhibitors. 
Indexing Annotation English:   polypeptides from snake venom; platelet aggregation inhib
Pharmacological Action:   Platelet Aggregation Inhibitors
 
History Note English:   97; was DISINTEGRINS (NM) 1992-96 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UR urine  
Record Number:   33035 
Unique Identifier:   D019483 

Occurrence in VHL: 		 

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