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DOXEPIN
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DeCS
Descriptor
English
:
Doxepin
Descriptor
Spanish
:
Doxepina
Descriptor
Portuguese
:
Doxepina
Tree Number:
D02.355.291.852.500
D03.494.382.393
Definition
English
:
A dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is not fully understood, but it appears to block reuptake of monoaminergic neurotransmitters into
presynaptic terminals
. It also possesses anticholinergic activity and modulates antagonism of
histamine
H(1)- and H(2)-receptors.
Pharmacological Action:
Antidepressive Agents, Tricyclic
Histamine Antagonists
History Note
English
:
74
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
EC
economics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
4375
Unique Identifier:
D004316
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS