Search on:
EPIPODOPHYLLOTOXIN
Descriptors Found:
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DeCS
Descriptor
English
:
Podophyllotoxin
Descriptor
Spanish
:
Podofilotoxina
Descriptor
Portuguese
:
Podofilotoxina
Synonyms
English
:
Epipodophyllotoxin
Tree Number:
D02.455.426.559.389.140.450.777
D02.455.426.559.847.638.960.675
D04.615.638.960.675
Definition
English
:
A lignan (
LIGNANS
) found in
PODOPHYLLIN
resin from the roots of
PODOPHYLLUM
plants
. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irritating to skin and mucous
membranes
, has keratolytic actions, has been used to treat warts and keratoses, and may have antineoplastic properties, as do some of its congeners and derivatives.
Indexing Annotation
English
:
/biosyn permitted if by plant
Pharmacological Action:
Antineoplastic Agents, Phytogenic
Keratolytic Agents
Tubulin Modulators
History Note
English
:
73; EPIPODOPHYLLOTOXIN was see under PODOPHYLLOTOXIN 1975
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
11464
Unique Identifier:
D011034
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS