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PENTOSTATIN
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DeCS
Descriptor
English
:
Pentostatin
Descriptor
Spanish
:
Pentostatina
Descriptor
Portuguese
:
Pentostatina
Synonyms
English
:
2'-Deoxycoformycin
Tree Number:
D03.383.742.680.350.200.700
D13.570.230.677
D13.570.685.350.200.700
Definition
English
:
A potent inhibitor of
ADENOSINE DEAMINASE
. The drug induces
APOPTOSIS
of
LYMPHOCYTES
, and is used in the treatment of many lymphoproliferative malignancies, particularly HAIRY CELL
LEUKEMIA
. It is also synergistic with some other
antineoplastic agents
and has immunosuppressive activity.
Pharmacological Action:
Adenosine Deaminase Inhibitors
Antineoplastic Agents
History Note
English
:
90; for CO-VIDARABINE use PENTOSTATIN 1982-97
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
EC
economics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
24830
Unique Identifier:
D015649
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS