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PYROGLOBULINS
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DeCS
Descriptor
English
:
Pyroglobulins
Descriptor
Spanish
:
Piroglobulinas
Descriptor
Portuguese
:
Piroglobulinas
Tree Number:
D12.776.124.486.485.900.700
D12.776.124.790.651.900.700
D12.776.377.715.548.900.700
Definition
English
:
Atypical gamma
immunoglobulins
characterized by their irreversible heat denaturation at 56-degrees C. Pyroprecipitation is inhibited at pH below 3 and above 9. The presence of
pyroglobulins
in the serum is the cause of pyroglobulinemia. They are frequently present in
multiple myeloma
and the pyroglobulin precipitate binds complement, reacts with
rheumatoid factor
, produces
passive cutaneous anaphylaxis
, generalized passive
anaphylaxis
and passive Arthus-type phenomena.
Pharmacological Action:
Immunologic Factors
History Note
English
:
91(76); was see under PARAPROTEINS 1976-90
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
22273
Unique Identifier:
D011750
Occurrence in VHL
:
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DeCS
CID-10
SciELO
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