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ANISTREPLASE
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DeCS
Descriptor
English
:
Anistreplase
Descriptor
Spanish
:
Anistreplasa
Descriptor
Portuguese
:
Anistreplase
Synonyms
English
:
Anisoylated Plasminogen-Streptokinase Activator Complex
APSAC
Tree Number:
D08.811.277.656.300.760.635.075
D08.811.277.656.300.775.075
D08.811.277.656.959.350.635.075
D12.776.124.125.662.537.075
Definition
English
:
An acylated inactive complex of
streptokinase
and human lysine-plasminogen. After injection, the acyl group is slowly hydrolyzed, producing an activator that converts
plasminogen
to
plasmin
, thereby initiating
fibrinolysis
. Its
half-life
is about 90 minutes compared to 5 minutes for TPA; (
TISSUE PLASMINOGEN ACTIVATOR
); 16 minutes for
UROKINASE-TYPE PLASMINOGEN ACTIVATOR
and 23 minutes for
STREPTOKINASE
. If treatment is initiated within 3 hours of onset of symptoms for acute
myocardial infarction
, the drug preserves myocardial tissue and
left ventricular function
and increases coronary artery patency.
Bleeding
complications are
similar
to other thrombolytic agents.
Pharmacological Action:
Fibrinolytic Agents
History Note
English
:
91
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
28860
Unique Identifier:
D016255
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS