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NEOPLASIA, MULTIPLE ENDOCRINE TYPE 2B
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DeCS
Descriptor
English
:
Multiple Endocrine Neoplasia Type 2b
Descriptor
Spanish
:
Neoplasia Endocrina Múltiple Tipo 2b
Descriptor
Portuguese
:
Neoplasia Endócrina Múltipla Tipo 2b
Synonyms
English
:
MEN 2b
MEN 3
Neoplasia, Multiple Endocrine Type 2b
Neoplasms, Multiple Endocrine Type 2b
Tree Number:
C04.588.322.400.510
C04.651.600.510
C04.700.630.510
C16.320.700.630.510
C19.344.400.510
Definition
English
:
Similar
to MEN2A, it is also caused by mutations of the MEN2 gene, also known as the RET proto-oncogene. Its clinical symptoms include medullary
carcinoma
(
CARCINOMA
, MEDULLARY) of
THYROID GLAND
and
PHEOCHROMOCYTOMA
of
ADRENAL MEDULLA
(50%). Unlike MEN2a, MEN2b does not involve
PARATHYROID NEOPLASMS
. It can be distinguished from MEN2A by its neural abnormalities such as mucosal NEUROMAS on
EYELIDS
; LIP; and
TONGUE
, and ganglioneuromatosis of
GASTROINTESTINAL TRACT
leading to
MEGACOLON
. It is an autosomal dominant inherited
disease.
Indexing Annotation
English
:
coordinate IM with specific endocrine/neoplasm pre-coordinates (IM) + specific histological type (IM) if pertinent
History Note
English
:
1995; MEA III & MEN III see NEOPLASMS, MULTIPLE ENDOCRINE 1983-1994
Allowable Qualifiers
English
:
BS
blood supply
BL
blood
CF
cerebrospinal fluid
CI
chemically induced
CH
chemistry
CL
classification
CO
complications
CN
congenital
DI
diagnosis
DH
diet therapy
DT
drug therapy
EC
economics
EM
embryology
EN
enzymology
EP
epidemiology
EH
ethnology
ET
etiology
GE
genetics
HI
history
IM
immunology
ME
metabolism
MI
microbiology
MO
mortality
NU
nursing
PS
parasitology
PA
pathology
PP
physiopathology
PC
prevention & control
PX
psychology
RA
radiography
RI
radionuclide imaging
RT
radiotherapy
RH
rehabilitation
SC
secondary
SE
secretion
SU
surgery
TH
therapy
US
ultrasonography
UL
ultrastructure
UR
urine
VE
veterinary
VI
virology
Record Number:
32132
Unique Identifier:
D018814
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
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