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SPLEEN FOCUS-FORMING VIRUSES
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DeCS
Descriptor
English
:
Spleen Focus-Forming Viruses
Descriptor
Spanish
:
Virus Formadores de Foco en el Bazo
Descriptor
Portuguese
:
Vírus Formadores de Foco no Baço
Synonyms
English
:
Friend spleen focus-forming virus
Rauscher Spleen Focus-Forming Virus
Tree Number:
B04.613.807.375.525.850
B04.820.650.375.525.850
Definition
English
:
Strains of MURINE
LEUKEMIA
VIRUS that are replication-defective and rapidly transforming. The envelope gene plays an essential role in initiating erythroleukemia (
LEUKEMIA
, ERYTHROBLASTIC, ACUTE), manifested by splenic foci,
SPLENOMEGALY
, and
POLYCYTHEMIA
.
Spleen focus-forming viruses
are generated by recombination with endogenous retroviral sequences.
Indexing Annotation
English
:
infection
: coordinate IM with
RETROVIRIDAE INFECTIONS
(IM) +
TUMOR VIRUS INFECTIONS
(IM) +
LEUKEMIA
, EXPERIMENTAL (IM) or
LEUKEMIA
, ERYTHROBLASTIC, ACUTE (IM) (for spontaneous erythroleukemia)
History Note
English
:
91(86); was see under MOUSE LEUKEMIA VIRUSES 1986-90
Allowable Qualifiers
English
:
CH
chemistry
CL
classification
DE
drug effects
EN
enzymology
GE
genetics
GD
growth & development
IM
immunology
IP
isolation & purification
ME
metabolism
PY
pathogenicity
PH
physiology
RE
radiation effects
UL
ultrastructure
Record Number:
19525
Unique Identifier:
D013155
Occurrence in VHL
:
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CID-10
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