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ALPHA-TRANSDUCIN
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DeCS
Descriptor
English
:
Transducin
Descriptor
Spanish
:
Transducina
Descriptor
Portuguese
:
Transducina
Synonyms
English
:
alpha-Transducin
beta-Transducin
gamma-Transducin
G-Protein, Inhibitory Gt
Gt, Transducin G-Protein
Tree Number:
D08.811.277.040.330.300.200.800
D12.644.360.375.940
D12.776.157.325.332.940
D12.776.476.375.940
D12.776.543.325.800
Definition
English
:
A heterotrimeric GTP-binding protein that mediates the light activation signal from photolyzed
rhodopsin
to
cyclic GMP
phosphodiesterase and is pivotal in the visual excitation process. Activation of
rhodopsin
on the outer membrane of rod and cone cells causes GTP to bind to
transducin
followed by dissociation of the alpha subunit-GTP complex from the beta/gamma subunits of
transducin
. The alpha subunit-GTP complex activates the
cyclic GMP
phosphodiesterase which catalyzes the
hydrolysis
of
cyclic GMP
to 5'-GMP. This leads to closure of the
sodium
and
calcium channels
and therefore hyperpolarization of the rod cells. EC 3.6.1.-.
Indexing Annotation
English
:
alpha, beta and gamma transducins refer to its subunits
History Note
English
:
89
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
23850
Unique Identifier:
D015293
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS