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PRO-OPIOMELANOCORTIN
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DeCS
Descriptor
English
:
Pro-Opiomelanocortin
Descriptor
Spanish
:
Proopiomelanocortina
Descriptor
Portuguese
:
Pró-Opiomelanocortina
Synonyms
English
:
POMC
Pro-Opiocortin
Tree Number:
D06.472.699.327.935
D06.472.699.631.525.600
D12.644.400.400.935
D12.644.548.365.935
D12.644.548.691.525.690
D12.776.641.650.405.935
D12.776.811.800
Definition
English
:
A 30-kDa protein synthesized primarily in the ANTERIOR
PITUITARY GLAND
and the
HYPOTHALAMUS
. It is also found in the skin and other peripheral
tissues
. Depending on species and
tissues
, POMC is cleaved by PROHORMONE CONVERTASES yielding various active
peptides
including ACTH;
BETA-LIPOTROPIN
;
ENDORPHINS
;
MELANOCYTE-STIMULATING HORMONES
; and others (GAMMA-LPH;
CORTICOTROPIN-LIKE INTERMEDIATE LOBE PEPTIDE
; N-terminal peptide of POMC or NPP).
History Note
English
:
1985
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
21050
Unique Identifier:
D011333
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS