Search on: 1,4,5-INSP3 
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Descriptor English:   Inositol 1,4,5-Trisphosphate 
Descriptor Spanish:   Inositol 1,4,5-Trifosfato 
Descriptor Portuguese:   Inositol 1,4,5-Trisfosfato 
Synonyms English:   Inositol 1,4,5-Triphosphate
1,4,5-InsP3
Myo-Inositol 1,4,5-Trisphosphate  
Tree Number:   D02.033.800.519.400.350
D09.853.519.400.350
D09.894.480.350
Definition English:   Intracellular messenger formed by the action of phospholipase C on phosphatidylinositol 4,5-bisphosphate, which is one of the phospholipids that make up the cell membrane. Inositol 1,4,5-trisphosphate is released into the cytoplasm where it releases calcium ions from internal stores within the cell's endoplasmic reticulum. These calcium ions stimulate the activity of B kinase or calmodulin. 
History Note English:   90 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AA analogs & derivatives
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UR urine
Record Number:   24744 
Unique Identifier:   D015544 

Occurrence in VHL:
 

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