Search on: 1-METHYL-4-PHENYLPYRIDINIUM 
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Descriptor English:   1-Methyl-4-phenylpyridinium 
Descriptor Spanish:   1-Metil-4-fenilpiridinio 
Descriptor Portuguese:   1-Metil-4-fenilpiridínio 
Synonyms English:   Cyperquat  
Tree Number:   D03.383.725.762.550
Definition English:   An active neurotoxic metabolite of 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE. The compound reduces dopamine levels, inhibits the biosynthesis of catecholamines, depletes cardiac norepinephrine and inactivates tyrosine hydroxylase. These and other toxic effects lead to cessation of oxidative phosphorylation, ATP depletion, and cell death. The compound, which is related to PARAQUAT, has also been used as an herbicide. 
Pharmacological Action:   Herbicides
 
See Related English:   MPTP Poisoning
 
History Note English:   90 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AA analogs & derivatives
AN analysis AI antagonists & inhibitors
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
EC economics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UR urine
Record Number:   24778 
Unique Identifier:   D015655 

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