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12-LIPOXYGENASE
Descriptors Found:
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DeCS
Descriptor
English
:
Arachidonate 12-Lipoxygenase
Descriptor
Spanish
:
Araquidonato 12-Lipooxigenasa
Descriptor
Portuguese
:
Araquidonato 12-Lipoxigenase
Synonyms
English
:
12-Lipoxygenase
Tree Number:
D08.811.682.690.416.583.500.060
D12.776.556.579.374.568.500.025
Definition
English
:
An enzyme that catalyzes the
oxidation
of
arachidonic acid
to yield 12-hydroperoxyarachidonate (12-HPETE) which is itself rapidly converted by a
peroxidase
to 12-hydroxy-5,8,10,14-eicosatetraenoate (12-HETE). The 12-hydroperoxides are preferentially formed in PLATELETS.
Entry Combination - descr/qualif
English
:
Arachidonate 12-Lipoxygenase
/
antagonists & inhibitors
use
Lipoxygenase Inhibitors
History Note
English
:
91(87); was see under ARACHIDONATE LIPOXYGENASES 1987-90
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
19075
Unique Identifier:
D001092
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
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