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DeCS
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Descriptor English:
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Steroid 12-alpha-Hydroxylase
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Descriptor Spanish:
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Esteroide 12-alfa-Hidroxilasa
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Descriptor Portuguese:
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Esteroide 12-alfa-Hidroxilase
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Synonyms English:
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12-alpha-Hydroxylase
Steroid 12-Monooxygenase
Sterol 12-alpha-Hydroxylase
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Tree Number:
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D08.244.453.915.730
D08.811.682.690.708.170.915.730
D12.776.422.220.453.915.730
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Definition English:
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A liver microsomal cytochrome P450 enzyme that catalyzes the 12-alpha-hydroxylation of a broad spectrum of sterols in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP8B1gene, converts 7-alpha-hydroxy-4-cholesten-3-one to 7-alpha-12-alpha-dihydroxy-4-cholesten-3-one and is required in the synthesis of BILE ACIDS from cholesterol. |
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History Note English:
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2003 (1978)
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Allowable Qualifiers English:
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Record Number:
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29288
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Unique Identifier:
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D013253
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Occurrence in VHL:
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Similar:
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DeCS CID-10 SciELO LILACS LIS
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