Search on: 4-QUINOLONES 
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Descriptor English:   4-Quinolones 
Descriptor Spanish:   4-Quinolonas 
Descriptor Portuguese:   4-Quinolonas 
Tree Number:   D03.438.810.835.055
Definition English:   QUINOLONES containing a 4-oxo (a carbonyl in the para position to the nitrogen). They inhibit the A subunit of DNA GYRASE and are used as antimicrobials. Second generation 4-quinolones are also substituted with a 1-piperazinyl group at the 7-position and a fluorine at the 6-position. 
History Note English:   2004 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications EC economics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UR urine  
Record Number:   38097 
Unique Identifier:   D042462 

Occurrence in VHL:
 

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