Search on: DIDANOSINE 
Descriptors Found: 1
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Descriptor English:   Didanosine 
Descriptor Spanish:   Didanosina 
Descriptor Portuguese:   Didanosina 
Synonyms English:   ddI (Antiviral)
2',3'-Dideoxyinosine
Dideoxyinosine  
Tree Number:   D03.438.759.590.616.130
D13.570.230.500.090
D13.570.583.616.130
D13.570.800.573.130
Definition English:   A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase; ddI is then metabolized to dideoxyadenosine triphosphate, its putative active metabolite. 
Pharmacological Action:   Anti-HIV Agents
Antimetabolites
Reverse Transcriptase Inhibitors
 
History Note English:   92; was DIDEOXYINOSINE 1990-91 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AA analogs & derivatives
AN analysis AI antagonists & inhibitors
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
EC economics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UR urine
Record Number:   30328 
Unique Identifier:   D016049 

Occurrence in VHL:
 

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