Search on: MEGLUTOL 
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Descriptor English:   Meglutol 
Descriptor Spanish:   Meglutol 
Descriptor Portuguese:   Meglutol 
Synonyms English:   3-Hydroxy-3-methylglutaric Acid  
Tree Number:   D02.241.081.337.351.550
Definition English:   An antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids. It acts by interfering with the enzymatic steps involved in the conversion of acetate to hydroxymethylglutaryl coenzyme A as well as inhibiting the activity of HYDROXYMETHYLGLUTARYL COA REDUCTASES which is the rate limiting enzyme in the biosynthesis of cholesterol. 
Pharmacological Action:   Anticholesteremic Agents
Enzyme Inhibitors
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Hypolipidemic Agents
 
History Note English:   96; was 3-HYDROXY-3-METHYLGLUTARIC ACID 1980-95 (see under GLUTARATES 1980-90) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AA analogs & derivatives
AN analysis AI antagonists & inhibitors
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
EC economics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UR urine
Record Number:   7073 
Unique Identifier:   D015093 

Occurrence in VHL:
 

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