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OSTEOPROTEGERIN
Descriptors Found:
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DeCS
Descriptor
English
:
Osteoprotegerin
Descriptor
Spanish
:
Osteoprotegerina
Descriptor
Portuguese
:
Osteoprotegerina
Synonyms
English
:
Osteoclastogenesis Inhibitory Factor
Receptors, Tumor Necrosis Factor, Member 11b
Tumor Necrosis Factor Receptor Superfamily, Member 11b
Tree Number:
D12.776.543.750.705.852.760.949.249
Definition
English
:
A secreted member of the TNF receptor superfamily that negatively regulates osteoclastogenesis. It is a soluble decoy receptor of
RANK LIGAND
that inhibits both
CELL DIFFERENTIATION
and function of
OSTEOCLASTS
by inhibiting the interaction between
RANK LIGAND
and
RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B
.
History Note
English
:
2007(1997)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
52396
Unique Identifier:
D053244
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
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